منابع مشابه
Cell-based angiopoietin-1 gene therapy for acute lung injury.
RATIONALE The acute respiratory distress syndrome is a significant cause of morbidity and mortality in critically ill patients. Angiopoietin-1 (Ang-1), a ligand for the endothelial Tie2 receptor, is an endothelial survival and vascular stabilization factor that reduces endothelial permeability and inhibits leukocyte-endothelium interactions. OBJECTIVES We hypothesized that Ang-1 counteracts v...
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Many pharmacological therapies have been investigated for use in acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS). These therapies can broadly be classified as being either anti-inflammatory or physiology based. Despite promising pre-clinical and small clinical studies almost all therapies have been shown to be unsuccessful in large scale randomized controlled trials. ...
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OBJECTIVE Bone marrow-derived mesenchymal stem cells (MSCs) can serve as a vehicle for gene therapy. FGF2 (basic fibroblast growth factor) is a multifunctional growth factor and exhibits diverse function in different cell types, it also has pleiotropic effects in different tissues and organs, including potent angiogenic effects and an important role in the differentiation and function of the ce...
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A CUTE lung injury (ALI) and acute respiratory distress syndrome remain one of the most common causes of acute respiratory failure in critically ill patients. Despite extensive research, current treatment options remain primarily supportive with lung protective ventilation and a fluid conservative strategy. Recently, the potential use of cell-based therapy has generated considerable interest fo...
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Today, stem cell transplantation is a hot topic in scientific circles as a novel therapeutic approach to repair the structure and function of central nervous system. The safe and neuroprotective effects of cell therapy in models and traumatic brain injury patients were evaluated in many experimental and clinical studies in recent decade and somewhat promising results were provided to the scient...
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ژورنال
عنوان ژورنال: Anesthesiology
سال: 2012
ISSN: 0003-3022
DOI: 10.1097/aln.0b013e3182567fc5